Anti-HIV-1 integrase and anti-allergic activities of Bauhinia strychnifolia
نویسندگان
چکیده
A stem ethanol extract of Bauhinia strychnifolia and its compounds were investigated for their anti-HIV-1 integrase (IN) and anti-allergic activities. From bioassay-guided isolation, five compounds including quercetin (1), 3,5,7,3',5'pentahydroxyflavanonol-3-O--L-rhamnopyranoside (2), 3,5,7-trihydroxychromone-3--L-rhamnopyranoside (3) and a mixture of -sitosterol (4) and stigmasterol (5) were isolated. Of the tested samples, compound 1 (quercetin) showed the highest activity against HIV-1 IN with an IC50 value of 15.2 μM, followed by 3 (3,5,7-trihydroxychromone-3--Lrhamnopyranoside), 4+5 (mixture of -sitosterol and stigmasterol) and 2 (3,5,7,3',5'-pentahydroxyflavanonol-3-O--Lrhamnopyranoside) with % inhibition of 28.2, 26.2 and 6.7 at 100 μM, respectively. With regard to anti-allergic activity, quercetin (1) possessed the highest anti-allergic activity with an IC50 of 8.1 μM, followed by 3 (3,5,7-trihydroxychromone-3-L-rhamnopyranoside) and 4+5 (mixture of -sitosterol and stigmasterol) with IC50 values of 52.1 and 77.5 μM, respectively. Compound 2 (3,5,7,3',5'-pentahydroxyflavanonol-3-O--L-rhamnopyranoside) was inactive. The present study is the first report of chemical constituents and biological activities of Bauhinia strychnifolia.
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